Additivity of inhibitory effects in multidrug combinations
نویسندگان
چکیده
منابع مشابه
Additivity of dilantin and vinblastine inhibitory effects on microtubule assembly.
Dilantin (phenytoin) is a commonly used antiepileptic agent that is known to decrease conductance of sodium and calcium ions and delay outward potassium currents. Separate from its antiseizure activity, dilantin interferes with microtubule protein polymerization. It induces metaphase arrest and potentiates the effects of the antimitotics vincristine and vinblastine in cell culture. We show here...
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ژورنال
عنوان ژورنال: Nature Microbiology
سال: 2018
ISSN: 2058-5276
DOI: 10.1038/s41564-018-0252-1